Major
Carbamazepine × Lamotrigine
Antiepileptics. Carboxamide derivatives×Antiepileptic with dual mechanism
Mechanism
Carbamazepine induces UGT1A4. Lamotrigine falls 50% – seizure breakthrough risk.
Symptoms
Seizure recurrence on previously effective dose.
Management
Double lamotrigine dose with blood level monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.