MajorAntiepileptic with dual mechanism×Antiepileptic, hydantoin derivative (sodium channel blocker)
Updated · Methodology
Mechanism
Phenytoin induces UGT1A4. Lamotrigine falls 50%.
Symptoms
Seizure breakthrough.
Management
Double lamotrigine dose.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lamictal (lamotrigine) prescribing information, boxed warning (2009)
- AEMPS: Ficha técnica: Lamotrigina (nº registro 65284), sección 4.5 (2025)– AEMPS, CIMA, nº registro 65284, revisión 09/2025, sección 4.5