Major
Lamotrigine × Rifampicin
Antiepileptic with dual mechanism×Antituberculous antibiotic
Mechanism
Rifampicin induces UGT1A4. Lamotrigine falls 40%.
Symptoms
Seizure breakthrough.
Management
Increase lamotrigine by 50-100%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.