MajorAntiepileptic with dual mechanism×Antituberculous antibiotic
Updated · Methodology
Mechanism
Rifampicin induces UGT1A4. Lamotrigine falls 40%.
Symptoms
Seizure breakthrough.
Management
Increase lamotrigine by 50-100%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lamictal (lamotrigine) prescribing information, boxed warning (2009)
- AEMPS: Ficha técnica: Lamotrigina (nº registro 65284), sección 4.5 (2025)– AEMPS, CIMA, nº registro 65284, revisión 09/2025, sección 4.5