MajorAntiepileptic, hydantoin derivative (sodium channel blocker)×Methylxanthine
Updated · Methodology
Mechanism
Phenytoin induces CYP1A2. Theophylline falls 30-50%.
Symptoms
Return of obstructive symptoms.
Management
Theophylline level monitoring with dose adjustment.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- DailyMed: Theophylline: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Teofilina (nº registro 45303), sección 4.5 (2024)– AEMPS, CIMA, nº registro 45303, revisión 12/2024, sección 4.5