MajorAntiepileptics. Carboxamide derivatives×Methylxanthine
Updated · Methodology
Mechanism
Carbamazepine induces CYP1A2, which partly metabolises theophylline. Theophylline plasma levels fall by 25–50%; bronchodilator effect weakens.
Symptoms
Recurrence of asthma or COPD symptoms: dyspnoea, wheezing.
Management
During carbamazepine therapy, increase theophylline by 50% with level monitoring at 1–2 weeks. Alternative anticonvulsants without induction: levetiracetam, lamotrigine.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Tegretol section 7 (2009)– ; DailyMed setid 8d409411-aa9f-4f3a-a52c-fbcb0c3ec053
- AEMPS: Ficha técnica: Carbamazepina (nº registro 62621), sección 4.5 (2025)– AEMPS, CIMA, nº registro 62621, sección 4.5
- AEMPS: Ficha técnica: Teofilina (nº registro 45303), sección 4.5 (2024)– AEMPS, CIMA, nº registro 45303, revisión 12/2024, sección 4.5