MajorAntituberculous antibiotic×Methylxanthine
Updated · Methodology
Mechanism
Rifampicin induces CYP1A2 and CYP3A4. Theophylline falls 50% – bronchoconstriction breakthrough risk.
Symptoms
Return of dyspnoea, bronchospasm.
Management
Double theophylline dose with blood level monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Theo-24 (theophylline) section 7 (2011)– ; DailyMed setid 7a108fa0-c230-475f-be93-6f864b98a410
- DailyMed: Theophylline: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Rifampicina (nº registro 49034), sección 4.5 (2026)– AEMPS, CIMA, nº registro 49034, revisión 08/2026, sección 4.5
- AEMPS: Ficha técnica: Teofilina (nº registro 45303), sección 4.5 (2024)– AEMPS, CIMA, nº registro 45303, revisión 12/2024, sección 4.5