MajormTOR kinase inhibitor – immunosuppressant and antineoplastic×Antituberculous antibiotic
Updated · Methodology
Mechanism
Rifampicin is a strong CYP3A4 inducer. Everolimus falls 60% – transplant rejection risk.
Symptoms
Transplant rejection signs.
Management
Alternative TB regimen without rifampicin. If necessary – double everolimus with frequent blood level monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Votubia (everolimus) EPAR – EMA (2024)– EMA EPAR Certican
- AEMPS: Ficha técnica: Everolimus (nº registro 84203), sección 4.5 (2024)– AEMPS, CIMA, nº registro 84203, sección 4.5