CriticalMacrolide antibiotic×mTOR kinase inhibitor – immunosuppressant and antineoplastic
Updated · Methodology
Mechanism
Clarithromycin inhibits CYP3A4 and P-gp. Everolimus rises 5+ fold – severe immunosuppression, pneumonitis, nephrotoxicity.
Symptoms
Dyspnoea, rising creatinine, cytopenia.
Management
Combination contraindicated. Alternative – azithromycin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Votubia (everolimus) EPAR – EMA (2024)– EMA EPAR Certican
- AEMPS: Ficha técnica: Everolimus (nº registro 84203), sección 4.5 (2024)– AEMPS, CIMA, nº registro 84203, sección 4.5