Critical
Cobicistat × Everolimus
Pharmacokinetic enhancer (booster) for antiretroviral therapy×mTOR kinase inhibitor – immunosuppressant and antineoplastic
Mechanism
Cobicistat is a strong CYP3A4 inhibitor (similar to ritonavir). Everolimus rises 10+ fold.
Symptoms
Acute immunosuppression.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Certican (everolimus) SmPC (2024)– EMA EPAR Certican