Critical
Everolimus × ritonavir
mTOR kinase inhibitor – immunosuppressant and antineoplastic×HIV protease inhibitor / pharmacokinetic booster
Mechanism
Strongest CYP3A4 inhibitor. Everolimus rises 15-fold.
Symptoms
Acute nephrotoxicity, pneumonitis.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Certican (everolimus) SmPC (2024)– EMA EPAR Certican