Critical
Isavuconazole × Rifampicin
Second-generation systemic triazole antifungal×Antituberculous antibiotic
Mechanism
Rifampicin is a strong CYP3A4 inducer. Isavuconazole falls 97% – antifungal effect lost.
Symptoms
Fungal infection progression.
Management
Combination contraindicated. EMA Cresemba Section 4.3.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Cresemba (isavuconazole) SmPC (2024)– EMA EPAR Cresemba