CriticalSecond-generation systemic triazole antifungal×Antituberculous antibiotic
Updated · Methodology
Mechanism
Rifampicin is a strong CYP3A4 inducer. Isavuconazole falls 97% – antifungal effect lost.
Symptoms
Fungal infection progression.
Management
Combination contraindicated. EMA Cresemba Section 4.3.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Cresemba (isavuconazole) SmPC (2024)– EMA EPAR Cresemba