Critical
Isavuconazole × Phenytoin
Second-generation systemic triazole antifungal×Antiepileptic, hydantoin derivative (sodium channel blocker)
Mechanism
Strong CYP3A4 induction.
Symptoms
Mycosis progression.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Cresemba (isavuconazole) SmPC (2024)– EMA EPAR Cresemba