Major
Rifampicin × Ticagrelor
Antituberculous antibiotic×Reversible P2Y12 receptor inhibitor
Mechanism
Strong CYP3A4 inducer – ticagrelor falls 86%. Antiplatelet effect lost – stent thrombosis risk.
Symptoms
Stent thrombosis, MI.
Management
Combination contraindicated. Alternative – clopidogrel or prasugrel.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.