CriticalSecond-generation HIV protease inhibitor×Antituberculous antibiotic
Updated · Methodology
Mechanism
Strong CYP3A4 induction – darunavir falls 80%. ART failure.
Symptoms
Rising viral load.
Management
Combination contraindicated. Alternative – rifabutin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Prezista (darunavir) SmPC (2024)– EMA EPAR Prezista
- AEMPS: Ficha técnica: Darunavir (nº registro 83164), sección 4.3 (2024)– AEMPS, CIMA, nº registro 83164, revisión 02/2024, sección 4.3