Critical
Darunavir × Rifampicin
Second-generation HIV protease inhibitor×Antituberculous antibiotic
Mechanism
Strong CYP3A4 induction – darunavir falls 80%. ART failure.
Symptoms
Rising viral load.
Management
Combination contraindicated. Alternative – rifabutin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Prezista (darunavir) SmPC (2024)– EMA EPAR Prezista