CriticalSecond-generation HIV protease inhibitor×HMG-CoA reductase inhibitors (statins)
Updated · Methodology
Mechanism
Darunavir inhibits CYP3A4. Simvastatin rises 10+ fold – fatal rhabdomyolysis.
Symptoms
Myalgia, CK above 50× ULN.
Management
Combination contraindicated. Pravastatin or rosuvastatin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Prezista (darunavir) SmPC (2024)– EMA EPAR Prezista
- AEMPS: Ficha técnica: Simvastatina (nº registro 65199), sección 4.3 (2026)– AEMPS, CIMA, nº registro 65199, revisión 03/2026, sección 4.3