MajorHMG-CoA reductase inhibitors (statins)×Reversible P2Y12 receptor inhibitor
Updated · Methodology
Mechanism
Ticagrelor inhibits P-glycoprotein. Simvastatin rises 1.5-fold. FDA Brilinta caps simvastatin at 40 mg/day.
Symptoms
Myalgia, rising CK.
Management
Cap simvastatin at 40 mg/day.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Brilinta (ticagrelor) prescribing information, Section 4.3 (2015)
- AEMPS: Ficha técnica: Ticagrelor (nº registro 89536), sección 4.5 (2026)– AEMPS, CIMA, nº registro 89536, sección 4.5
- AEMPS: Ficha técnica: Simvastatina (nº registro 65199), sección 4.5 (2026)– AEMPS, CIMA, nº registro 65199, revisión 03/2026, sección 4.5