Critical
Atazanavir × Rifampicin
Antiretroviral, HIV protease inhibitor×Antituberculous antibiotic
Mechanism
Strong CYP3A4 induction – atazanavir falls 80%. ART failure.
Symptoms
Rising viral load.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Reyataz (atazanavir) SmPC (2024)– EMA EPAR Reyataz