CriticalErgot alkaloid, 5-HT1B/1D and alpha-adrenoceptor agonist×HIV protease inhibitor / pharmacokinetic booster
Updated · Methodology
Mechanism
Ritonavir is the strongest ARV CYP3A4 inhibitor. Fatal ergotism.
Symptoms
Digital ischaemia, stroke.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Migranal (dihydroergotamine) prescribing information (2020)– FDA Migranal label, Section 4
- AEMPS: Ficha técnica: Ritonavir (nº registro 81039), sección 4.3 (2025)– AEMPS, CIMA, nº registro 81039, revisión 04/2025, sección 4.3