CriticalClass III antiarrhythmic, selective IKr blocker×Non-dihydropyridine calcium channel blocker
Updated · Methodology
Mechanism
Verapamil inhibits renal OCT2 transporter that clears dofetilide. Dofetilide doubles, QT prolongs. FDA Tikosyn Section 4.3 strict contraindication.
Symptoms
Torsades de pointes within hours.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Tikosyn (dofetilide) prescribing information (2019)– FDA Tikosyn label, Section 4 Contraindications
- AEMPS: Ficha técnica: Verapamilo, Manidon Retard 120 mg (nº registro 53434), sección 4.5 (2024)– AEMPS, CIMA, nº registro 53434, revisión 06/2024, sección 4.5