MajorClass III antiarrhythmics (Vaughan Williams)×Non-dihydropyridine calcium channel blocker
Updated · Methodology
Mechanism
Additive suppression of sinus node and atrioventricular (AV) conduction. Symptomatic bradycardia, sinoatrial and AV block have been reported.
Symptoms
Bradycardia (heart rate below 50/min), dizziness, syncope. ECG: first- to second-degree AV block. Older patients: fall risk.
Management
Avoid the combination. In atrial fibrillation, choose one strategy: amiodarone for rhythm control, verapamil for rate control. Alternatives: a beta-blocker + digoxin or catheter ablation.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Verapamil hydrochloride tablet (Zydus Lifesciences Limited) – Prescribing Information (2017)– ; DailyMed setid 051392d3-8ec1-450c-8c38-791d4ef1a2db
- AEMPS: Ficha técnica: Amiodarona (nº registro 81291), sección 4.4 (2022)– AEMPS, CIMA, nº registro 81291, revisión 06/2022, sección 4.4