Major
Bisoprolol × Verapamil
Selective beta-adrenergic blockers×Non-dihydropyridine calcium channel blocker
Mechanism
Additive AV slowing and reduced contractility. Bradycardia, AV block.
Symptoms
Bradycardia, AV block.
Management
Avoid combination.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.