MajorSelective beta-adrenergic blockers×Non-dihydropyridine calcium channel blocker
Updated · Methodology
Mechanism
Additive AV slowing and reduced contractility. Bradycardia, AV block.
Symptoms
Bradycardia, AV block.
Management
Avoid combination.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- ESC: 2023 ESC Guidelines for the management of acute coronary syndromes (2023)– Byrne RA, Rossello X, Coughlan JJ, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720–3826
- FDA: Verapamil hydrochloride tablet (Zydus Lifesciences Limited) – Prescribing Information section 7 (2017)– ; DailyMed setid 051392d3-8ec1-450c-8c38-791d4ef1a2db
- DailyMed: Verapamil: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Bisoprolol (nº registro 78903), sección 4.4 (2026)– AEMPS, CIMA, nº registro 78903, revisión 05/2026, sección 4.4