Moderate
Alprazolam × Bisoprolol
Benzodiazepines. Short-to-medium-acting anxiolytics×Selective beta-adrenergic blockers
Mechanism
Additive bradycardia and hypotension. Alprazolam sedation may mask early symptoms of excessive blood pressure drop.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk. With additional antihypertensives: bradycardia (pulse below 60/min).
Management
The combination is acceptable for short alprazolam use with pulse and blood pressure monitoring. In older patients, lorazepam at minimum doses is preferable with fall risk warning.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.