ModerateSelective beta-adrenergic blockers×Glucocorticoids
Updated · Methodology
Mechanism
Dexamethasone causes sodium and water retention via mineralocorticoid effect, reducing the antihypertensive effect of the beta-blocker.
Symptoms
Gradual blood pressure rise 2–4 weeks after starting the glucocorticoid. In heart failure: oedema, weight gain.
Management
For short dexamethasone courses (up to 7 days), no adjustment. For prolonged systemic therapy, increase bisoprolol or add a diuretic (hydrochlorothiazide, indapamide) with blood pressure monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Dexamethasone tablet (Pangea Pharmaceuticals, LLC) – Prescribing Information (2019)– ; DailyMed setid a41e6e26-9ebb-4b06-866e-a24af21c644c