ModerateSelective beta-adrenergic blockers×Atypical antipsychotics
Updated · Methodology
Mechanism
Additive hypotension (quetiapine blocks α1-adrenoceptors) and additive bradycardia.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk.
Management
The combination is acceptable at low quetiapine doses (≤300 mg/day). Check pulse and blood pressure 1–2 weeks after start. In older patients, olanzapine or aripiprazole (less α1-blockade) is preferable.
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Sources
- FDA: Seroquel (quetiapine) prescribing information (2017)– ; DailyMed setid 8ae62aaf-f8c5-417f-baac-0098369ca322