ModerateSelective beta-adrenergic blockers×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
NSAIDs weaken the antihypertensive effect of beta-blockers via renal prostaglandin suppression. Diclofenac is one of the most ulcerogenic NSAIDs with elevated cardiovascular risk.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting the NSAID. In chronic kidney disease: risk of fluid retention and oedema.
Management
Avoid prolonged diclofenac use. For acute pain: short course (5–7 days) with pantoprazole cover. For chronic analgesia: paracetamol, celecoxib, or topical NSAIDs.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Bisoprolol tablet (Micro Labs Limited) – Prescribing Information (2016)– ; DailyMed setid c3ee566c-74c4-45f4-a947-526a7313e326
- AEMPS: Ficha técnica: Bisoprolol (nº registro 78903), sección 4.5 (2026)– AEMPS, CIMA, nº registro 78903, revisión 05/2026, sección 4.5