MajorCalcium channel blockers (dihydropyridines)×Non-dihydropyridine calcium channel blocker
Updated · Methodology
Mechanism
Dual calcium channel blockade: amlodipine is a dihydropyridine blocker, verapamil is non-dihydropyridine. Additive hypotension, bradycardia, AV block risk.
Symptoms
Blood pressure drop, dizziness, syncope. Bradycardia, ECG first- to second-degree AV block. Older patients: fall risk.
Management
Avoid the combination. In hypertension, choose one calcium channel blocker (amlodipine or verapamil). For difficult hypertension, ACE-I + amlodipine + diuretic (without verapamil) or ACE-I + verapamil.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- ESH: 2023 ESH Guidelines for the management of arterial hypertension (2023)
- AEMPS: Ficha técnica: Amlodipino (nº registro 65461), sección 4.5 (2025)– AEMPS, CIMA, nº registro 65461, revisión 08/2025, sección 4.5