Critical
Erythromycin × Lovastatin
Macrolide antibiotic×HMG-CoA reductase inhibitor (statin)
Mechanism
CYP3A4 inhibition – lovastatin rises 5-fold. Rhabdomyolysis.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.