MajorClass III antiarrhythmics (Vaughan Williams)×HMG-CoA reductase inhibitor (statin)
Updated · Methodology
Mechanism
Amiodarone inhibits CYP3A4. Lovastatin rises 2-3 fold. FDA recommends capping lovastatin at 40 mg/day with amiodarone.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Cap lovastatin at 40 mg/day. Better – pravastatin or rosuvastatin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lovastatin tablets – Prescribing Information (2014)
- AEMPS: Ficha técnica: Amiodarona (nº registro 81291), sección 4.5 (2022)– AEMPS, CIMA, nº registro 81291, revisión 06/2022, sección 4.5