Major
fluvoxamine × Olanzapine
SSRI×Atypical antipsychotic – thienobenzodiazepine
Mechanism
Fluvoxamine is a strong CYP1A2 inhibitor. Olanzapine (CYP1A2 substrate) rises 2-3 fold.
Symptoms
Sedation, orthostatic hypotension, weight gain.
Management
Reduce olanzapine by 50%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.