MajorNon-steroidal anti-inflammatory drugs (NSAIDs)×Angiotensin II receptor blockers (sartans)
Updated · Methodology
Mechanism
NSAIDs reduce renal blood flow via prostaglandin blockade. The ARB (losartan) lowers glomerular pressure. The combination causes acute kidney injury, especially in older patients, chronic kidney disease, and dehydration.
Symptoms
Reduced urine output, rising creatinine and potassium, oedema. Symptoms appear earlier in older patients and in chronic kidney disease.
Management
Avoid prolonged combination. If ibuprofen is needed for a short course, use the minimum effective dose for 5–7 days with pantoprazole cover and creatinine monitoring. For chronic analgesia: paracetamol or celecoxib.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Cozaar (losartan) section 7 (2018)– ; DailyMed setid 9949448f-c3b9-44ee-94ed-c1aca8c90f39
- AEMPS: Ficha técnica: Losartan (nº registro 67729), sección 4.5 (2025)– AEMPS, CIMA, nº registro 67729, revisión 03/2025, sección 4.5