ModerateAngiotensin II receptor blockers (sartans)×Glucocorticoids
Updated · Methodology
Mechanism
Prednisolone retains sodium and water via mineralocorticoid effect, blunting the ARB's antihypertensive effect. Both also contribute to hyperkalaemia in CKD.
Symptoms
Return or rise of blood pressure, leg oedema. Weakness, fatigue, paraesthesias, arrhythmia. Symptoms develop at potassium above 5.5 mmol/L; life-threatening above 6.5 mmol/L.
Management
For short prednisolone courses (3–7 days), no specific adjustment needed. For long-term therapy, check BP weekly in the first month. If BP rises, increase losartan or add a thiazide. Potassium and creatinine every 2 weeks.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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