ModerateGlucocorticoids×Selective serotonin reuptake inhibitors (SSRIs)
Updated · Methodology
Mechanism
Prednisolone is ulcerogenic — suppresses prostaglandin synthesis and gastric mucosal turnover. Sertraline reduces platelet aggregation via serotonin uptake. Additive GI bleeding risk.
Symptoms
Epigastric pain, heartburn, black or tarry stools, blood in vomit, bruising. Higher risk in older patients and prior peptic ulcer disease.
Management
On the combination, in patients over 65, with prior peptic ulcer, or on long-term prednisolone (over 2 weeks), add pantoprazole 20 mg/day. For short courses (3–7 days), additional gastroprotection is not mandatory.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Warfarin sodium tablet (Amneal Pharmaceuticals LLC) – Prescribing Information (2017)– ; DailyMed setid 558b7a0d-5490-4c1b-802e-3ab3f1efe760