MajorNon-steroidal anti-inflammatory drugs (NSAIDs)×Glucocorticoids
Updated · Methodology
Mechanism
Similar to ibuprofen – additive GI bleeding risk. Diclofenac has a higher ulcerogenic potential among NSAIDs.
Symptoms
Black or tarry stools (melena), vomiting blood or coffee-ground material, epigastric pain. Risk multiplies in older patients and with prior peptic ulcer disease.
Management
Avoid prolonged combination. If diclofenac is needed, use the minimum effective dose for 5–7 days with mandatory pantoprazole cover. For chronic analgesia: paracetamol or celecoxib.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Diclofenac potassium tablet (Advagen Pharma Ltd) – Prescribing Information (2009)– ; DailyMed setid 82218d5c-1625-471a-aabe-f43338e5176b
- AEMPS: Ficha técnica: Diclofenaco (nº registro 62161), sección 4.4 (2025)– AEMPS, CIMA, nº registro 62161, revisión 08/2025, sección 4.4