CriticalOrganic nitrate, nitric oxide donor×Phosphodiesterase type 5 inhibitors (PDE5)
Updated · Methodology
Mechanism
Sildenafil and isosorbide dinitrate via cGMP – synergistic hypotension.
Symptoms
Fatal hypotension.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha tecnica de Iso-Mack (isosorbida dinitrato) (2023)– AEMPS CIMA, 2023
- AEMPS: Ficha técnica: Sildenafilo (nº registro 72231), sección 4.3 (2024)– AEMPS, CIMA, nº registro 72231, revisión 05/2024, sección 4.3