CriticalOrganic nitrate, nitric oxide donor×Phosphodiesterase type 5 (PDE-5) inhibitor
Updated · Methodology
Mechanism
Synergistic systemic vasodilation.
Symptoms
Fatal hypotension.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha tecnica de Cialis (tadalafilo) (2024)– AEMPS CIMA, 2024
- AEMPS: Ficha técnica: Tadalafilo (nº registro 85659), sección 4.3 (2025)– AEMPS, CIMA, nº registro 85659, revisión 12/2025, sección 4.3