Critical
Isosorbide mononitrate × Vardenafil
Long-acting organic nitrate×Phosphodiesterase type 5 (PDE-5) inhibitor
Mechanism
Same pharmacodynamics – synergistic hypotension.
Symptoms
Fatal hypotension.
Management
Combination contraindicated. 24-hour washout.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- AEMPS: Ficha tecnica de Levitra (vardenafilo) (2024)– AEMPS CIMA, 2024