CriticalHIV protease inhibitor / pharmacokinetic booster×Phosphodiesterase type 5 (PDE-5) inhibitor
Updated · Methodology
Mechanism
Ritonavir – CYP3A4 inhibitor. Vardenafil rises 13-fold.
Symptoms
Severe hypotension, QT prolongation.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha tecnica de Levitra (vardenafilo) (2024)– AEMPS CIMA, 2024
- AEMPS: Ficha técnica: Ritonavir (nº registro 81039), sección 4.5 (2025)– AEMPS, CIMA, nº registro 81039, sección 4.5
- AEMPS: Ficha técnica: Vardenafilo (nº registro 82920), sección 4.3 (2025)– AEMPS, CIMA, nº registro 82920, revisión 02/2025, sección 4.3