CriticalOpioid analgesic, phenylpiperidine class×Antidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B), amphetamine derivative
Updated · Methodology
Mechanism
Same pharmacodynamics – fatal serotonin syndrome.
Symptoms
Hyperthermia, myoclonus, coma.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Demerol (meperidine) prescribing information (2017)– FDA Demerol label, boxed warning serotonergic
- AEMPS: Ficha técnica: Tranilcipromina (nº registro 88524), sección 4.3 (2026)– AEMPS, CIMA, nº registro 88524, revisión 08/2026, sección 4.3
- AEMPS: Ficha técnica: Petidina (nº registro 89406), sección 4.5 (2026)– AEMPS, CIMA, nº registro 89406, revisión 10/2026, sección 4.5