Minor
Metoprolol × Paracetamol
Selective β1-adrenoceptor blockers×Anilides. Analgesics and antipyretics
Mechanism
Paracetamol is metabolised by CYP2E1 (5%) and predominantly by glucuronidation; metoprolol by CYP2D6. No direct pharmacokinetic interaction.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. Paracetamol remains the analgesic of choice in patients on metoprolol.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.