CriticalAntidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B)×SNRI (serotonin-norepinephrine reuptake inhibitor)
Updated · Methodology
Mechanism
Venlafaxine is an SNRI with strong serotonin effect. Combined with phenelzine causes severe serotonin syndrome.
Symptoms
Hyperthermia, myoclonus, tachycardia, rhabdomyolysis.
Management
Combination contraindicated. 2-week washout (1 week for venlafaxine due to short T½).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Nardil (phenelzine sulfate) prescribing information (2009)– FDA Nardil label, Section 4 Contraindications; DailyMed setid 513a41d0-37d4-4355-8a6d-a2c643bce6fa
- AEMPS: Ficha técnica: Venlafaxina (nº registro 67542), sección 4.3 (2024)– AEMPS, CIMA, nº registro 67542, revisión 03/2024, sección 4.3