MajorSelective serotonin reuptake inhibitors (SSRIs)×SNRI (serotonin-norepinephrine reuptake inhibitor)
Updated · Methodology
Mechanism
SSRI (sertraline) + SNRI (venlafaxine) – additive serotonergic load. The combination is not used in clinical practice.
Symptoms
Serotonin syndrome: agitation, confusion, tremor, myoclonus, hyperreflexia. Autonomic features: sweating, tachycardia, hypertension, fever. First signs appear within hours of co-administration.
Management
The combination is not prescribed. When switching antidepressants, allow a 1-week washout. For augmentation, add mirtazapine or agomelatine (different class).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Effexor + Zoloft drug interactions (2017)– ; DailyMed setid c848a5d8-ba94-4c84-80e3-0bf35fb8e32e