Major
Selegiline × Sumatriptan
Selective irreversible MAO-B inhibitor×Selective 5-HT1B/1D serotonin receptor agonist
Mechanism
Selegiline at high doses loses MAO-B selectivity and inhibits MAO-A. Serotonin syndrome risk with triptans.
Symptoms
Agitation, tachycardia, hypertension.
Management
Avoid combination, especially with selegiline above 10 mg/day. Alternative – paracetamol for migraine attack.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.