CriticalPotassium-sparing diuretics (mineralocorticoid receptor antagonists)×Potassium-sparing diuretic, collecting duct sodium channel blocker
Updated · Methodology
Mechanism
Both are potassium-sparing diuretics. Combined use produces dual potassium retention and severe hyperkalaemia with risk of fatal arrhythmia.
Symptoms
K+ above 6.5 mmol/L, muscle weakness, arrhythmia, ECG peaked T waves.
Management
Combination contraindicated. Choose one potassium-sparing diuretic.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →