MajorAngiotensin-converting enzyme inhibitors (ACEi)×Potassium-sparing diuretic, collecting duct sodium channel blocker
Updated · Methodology
Mechanism
Enalapril suppresses aldosterone – less potassium excreted. With triamterene additive hyperkalaemia, especially in CKD.
Symptoms
Hyperkalaemia within 2 weeks.
Management
Check potassium and creatinine at 1 and 4 weeks. Reduce triamterene if K+ above 5.0.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- DailyMed: Triamterene: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Enalapril (nº registro 63355), sección 4.5 (2025)– AEMPS, CIMA, nº registro 63355, revisión 08/2025, sección 4.5