Amino acid; participates in collagen synthesis and acts as a pH regulator replacing synthetic alkalis. In skin formulas works as a mild humectant.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Safe pH regulator and auxiliary humectant. Standalone clinical skin effects are limited.
Arginine is a conditionally essential α-amino acid. The natural substrate of NO synthase (NOS) – produces nitric oxide NO, which dilates vessels. In skin it participates in collagen, elastin, and urea synthesis. Mechanism. Several roles: humectant (binds water through free amino groups), pH adjuster (replaces synthetic alkalis in eco-formulas), collagen synthesis substrate (via L-arginine → L-citrulline → L-proline → collagen). At high topical concentrations (>5%) NO generation may improve microcirculation – a theoretical 'anti-dullness' rationale. Where applied. Anti-aging serums and creams (0.5–5%), eye-area creams, brightening masks, haircare. In Spain – Sesderma Acglicolic, Mesoestetic, Skeyndor. Evidence base. Few skin RCTs. Manufacturer in vitro studies show stimulation of collagen synthesis in fibroblast culture. Insufficient human clinical endpoints. Safety. CIR confirmed safety of amino acids in cosmetics. Hypoallergenic, non-irritating, non-comedogenic. Pregnancy and lactation – safe. Oral arginine in pregnancy is used for preeclampsia correction under physician supervision. Topical use – unrestricted. Functional role. A multitasking amino ingredient with a plausible mechanism and weak clinical base. Part of the NMF amino acid complex, not a standalone active.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Arginine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Arginine suits: normal, dry, oily, combination, sensitive.
Amino acid; participates in collagen synthesis and acts as a pH regulator replacing synthetic alkalis.
The INCI name is Arginine. It may also appear as: L-Arginine, Аргинин, L-Аргинин.
Published: · updated: