INCI: Sulisobenzone
Water-soluble UV filter with a medium protection spectrum. Formulators add it to clear gels and sprays, but the sensitization risk is higher than for newer filters.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Older member of the benzophenone family. Causes contact allergy more often than modern filters and gradually gives way to cleaner molecules.
Benzophenone-4 (Sulisobenzone) is a water-soluble organic UV filter with coverage across UVB and short UVA (290–360 nm). The sulfonate group makes the molecule polar and compatible with the aqueous phase of formulations – hence its place in clear gels and sprays. Mechanism. Absorbs UV photons and converts the energy to heat via reversible keto–enol tautomerism. Does not reflect light, unlike physical filters. Often combined with avobenzone to cover long-wave UVA and with titanium dioxide for extra UVB. Where applied. Sunscreen gels and sprays, tinted SPF liquid foundations, hair products with anti-fade protection, sports SPF formulas for pool and swimming. EU concentration up to 5%. In Spain part of ISDIN Fotoprotector Spray, Heliocare Color, and some Avène Eau Thermale Sunscreen lines. Safety. SCCS opinion 2008 confirmed safety at concentrations up to 5%. Allergic contact dermatitis in 0.5–1% of patients – more common than with newer filters such as Tinosorb S. Sensitisation occurs mainly in patients with systemic lupus erythematosus, photodermatoses, and long-term users. Not to be confused with benzophenone-3 (oxybenzone), which has stronger endocrine-activity signals and is being phased back in the EU. Pregnancy and lactation – use with caution. No direct endocrine activity for benzophenone-4 in human studies, but EFSA has requested more data on the benzophenone family. AEMPS does not ban it, but in pregnancy clinicians prefer physical filters (titanium dioxide, zinc oxide) and Tinosorb S/M. Controversies. Hawaii's 2018 ban applies to benzophenone-3 (oxybenzone) and octinoxate – benzophenone-4 is not banned, but the photofilter debate is active. EU and AEMPS monitor the data; no formal restrictions as of May 2026. Realistic assessment. A workable UVB–short UVA filter for clear formulas. Not a first pick in patients with photosensitive skin and systemic autoimmune disease. A good alternative is Tinosorb S or 4MBC in patients with a photo-allergy history.
Irritation potential
LowAllergen risk
ModeratePregnancy
CautionThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Benzophenone-4 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
Benzophenone-4 suits: normal, oily, combination. Use with caution in: sensitive.
Water-soluble UV filter with a medium protection spectrum.
The INCI name is Sulisobenzone.
Published: · updated:
Suitable for
Use with caution