Low-MW mixture of polysaccharides including hyaluronic acid.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Plant extract. Clinically meaningful effect on human skin is not supported by robust evidence; data limited to in vitro / lab models.
Hydrolyzed Glycosaminoglycans (GAGs) are a mixture of low-MW polysaccharides cleaved from natural glucosamine-containing polymers: hyaluronic acid, chondroitin, dermatan sulfate, heparan sulfate. Extracted from animal connective tissue or biosynthesized. Where applied. Moisturizing serums, creams, masks, "skin-rejuvenation" products (0.1-1%). In Spain in Sesderma Factor G, Skeyndor Power Hyaluronic, Martiderm Proteum. Evidence base. Direct clinical RCTs on hydrolyzed GAGs specifically are few. Data are extrapolated from hyaluronic acid and chondroitin: improved skin hydration and surface smoothing. The "dermal matrix repair" claim is not supported for topical use. Safety. CIR rated hydrolyzed GAGs safe at cosmetic concentrations (2010). Allergic reactions are rare; with animal-derived material there is theoretical risk in patients reactive to pork or beef. Pregnancy – safe topically. Lactation – no data, risk considered low.
Irritation potential
LowAllergen risk
LowPregnancy
UnknownThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Safety data for Hydrolyzed Glycosaminoglycans during pregnancy is insufficient. Best avoided when in doubt.
Low-MW mixture of polysaccharides including hyaluronic acid.
The INCI name is Hydrolyzed Glycosaminoglycans. It may also appear as: Гидролизованные гликозаминогликаны.
Published: · updated: