Hydrolyzed Glycosaminoglycans
Low-MW mixture of polysaccharides including hyaluronic acid.
Evidence by route
Topical application
Plant extract. Clinically meaningful effect on human skin is not supported by robust evidence; data limited to in vitro / lab models.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Unknown
About this ingredient
Hydrolyzed Glycosaminoglycans (GAGs) are a mixture of low-MW polysaccharides cleaved from natural glucosamine-containing polymers: hyaluronic acid, chondroitin, dermatan sulfate, heparan sulfate. Extracted from animal connective tissue or biosynthesized. Where applied. Moisturizing serums, creams, masks, "skin-rejuvenation" products (0.1-1%). In Spain in Sesderma Factor G, Skeyndor Power Hyaluronic, Martiderm Proteum. Evidence base. Direct clinical RCTs on hydrolyzed GAGs specifically are few. Data are extrapolated from hyaluronic acid and chondroitin: improved skin hydration and surface smoothing. The "dermal matrix repair" claim is not supported for topical use. Safety. CIR rated hydrolyzed GAGs safe at cosmetic concentrations (2010). Allergic reactions are rare; with animal-derived material there is theoretical risk in patients reactive to pork or beef. Pregnancy – safe topically. Lactation – no data, risk considered low.
Frequently asked questions
Is Hydrolyzed Glycosaminoglycans safe during pregnancy?
Safety data for Hydrolyzed Glycosaminoglycans during pregnancy is insufficient. Best avoided when in doubt.
What is Hydrolyzed Glycosaminoglycans and what does it do in cosmetics?
Low-MW mixture of polysaccharides including hyaluronic acid.
What's the INCI name for Hydrolyzed Glycosaminoglycans?
The INCI name is Hydrolyzed Glycosaminoglycans.
See Hydrolyzed Glycosaminoglycans in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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