Iscotrizinol
Highly stable UVB filter by Merck (Uvasorb HEB). Maintains protection under sunlight and pairs well with broad-spectrum UVA filters.
Evidence by route
Topical application
Lipophilic filter with a large molecule that barely penetrates skin. A good alternative to octinoxate in modern European sunscreens.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Iscotrizinol (Diethylhexyl Butamido Triazone, trade name Uvasorb HEB by Merck) is a highly photostable UVB filter. Developed by Merck in the 2000s, approved in EU since 2002 (Regulation 1223/2009 Annex VI), max 10%. Mechanism. Absorbs UVB (290-320 nm) peaking at 312 nm. High molecular weight (765 Da) – stays on skin surface, does not enter bloodstream. Lipid-soluble. Pairs well with broad-spectrum UVA filters (Tinosorb S/M, Mexoryl XL, Uvinul A Plus) for broad-spectrum protection. Where applied. Day creams with SPF, sunscreens, anti-aging formulas, water-resistant sunscreens. In Spain in Isdin Fotoprotector Fusion Water, Heliocare 360°, La Roche-Posay Anthelios. Often combined with Uvinul T 150 and Tinosorb S. Evidence base. SCCS 2005 (Opinion SCCNFP/0876/05) confirmed high photostability (>90% activity retention after 25 MED UV). Does not degrade in light, does not form toxic metabolites. SPF efficacy confirmed in instrumental in vitro and in vivo tests. Safety. CIR did not evaluate (filter registered in EU, not US). EU SCCS confirmed safety up to 10%. Minimal systemic absorption, no hormonal disruption (unlike oxybenzone and octinoxate), non-allergenic, non-comedogenic. EWG rates as a "safer" alternative to older filters. Pregnancy and lactation – safe topically. Suitable for all skin types, especially sensitive and photosensitive skin.
Frequently asked questions
Is Iscotrizinol safe during pregnancy?
Iscotrizinol should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Iscotrizinol for?
Iscotrizinol suits: normal, dry, oily, combination, sensitive.
What is Iscotrizinol and what does it do in cosmetics?
Highly stable UVB filter by Merck (Uvasorb HEB).
What's the INCI name for Iscotrizinol?
The INCI name is Diethylhexyl Butamido Triazone.
See Iscotrizinol in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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