Essential amino acid, NMF component. Functional formulation ingredient with no standalone activity on the skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Inert formulation ingredient. Safe, no standalone activity.
Lysine (L-Lysine) is an essential alpha-amino acid and a building block of collagen, elastin, and keratin. In cosmetics it is used as a humectant and conditioning agent. Mechanism. Humectant – pulls moisture from air and retains it in the stratum corneum. Participates in collagen cross-link formation (lysyl oxidase-dependent reaction), which supports skin density. Reduces protein glycation, protecting against age-related changes. Where applied. Serums, creams, masks, shampoos, conditioners (0.5–5%). In Spain in Sesderma Acglicolic and Martiderm lines. Often included in amino-acid complexes with proline, arginine, glycine. Evidence base. Few clinical RCTs on topical lysine; the main base is oral intake for herpes (Cochrane 2017, limited effect) and hair. CIR confirmed safety at cosmetic concentrations. Safety. Hypoallergenic, non-comedogenic. Pregnancy and lactation – topically safe at any stage.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Lysine is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Essential amino acid, NMF component.
The INCI name is Lysine. It may also appear as: Лизин.
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