Lysine HCl
Essential amino acid as the hydrochloride form. In skincare it's a component of amino-acid complexes for barrier support.
Evidence by route
Topical application
Safe amino acid for NMF complexes.
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Oily, Combination, Sensitive
About this ingredient
Lysine HCl is the hydrochloride salt of L-lysine, more water-soluble than free lysine. Used as a cosmetic amino acid for moisturizing and conditioning skin and hair. Mechanism. Humectant, supports stratum corneum integrity. As a salt, it incorporates easily into aqueous cosmetic bases. On hair it binds to negatively charged cuticle sites. Where applied. Creams, toners, hair masks, shampoos (0.5–3%). Often in damaged-hair formulas with arginine and glycine. In Spain in Martiderm and Sesderma lines. Evidence base. No topical clinical RCTs; lysine HCl is treated as functionally equivalent to free lysine. CIR confirmed safety. Safety. Hypoallergenic, non-comedogenic. Pregnancy and lactation – topically safe.
Frequently asked questions
Is Lysine HCl safe during pregnancy?
Lysine HCl is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Lysine HCl for?
Lysine HCl suits: normal, dry, oily, combination, sensitive.
What is Lysine HCl and what does it do in cosmetics?
Essential amino acid as the hydrochloride form.
What's the INCI name for Lysine HCl?
The INCI name is Lysine HCl. It may also appear as: L-Lysine HCl.
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